Discrete dynamics analysis for nonlinear collocated multivariable mass-damper-spring intelligent mechanical vibration systems

A new time-discretization method for the development of nonlinear collocated multivariable mass-damper-spring (MDS) intelligent mechanical vibration systems is proposed. It is based on the Runge-Kutta series expansion method and zero-order hold assumption. In this paper, we show that the mathematical structure of the new discretization scheme is explored and characterized in order to represent the discrete dynamics properties for nonlinear collocated multivariable MDS intelligent mechanical vibration systems. In particular, the decent effects of the time-discretization method on key properties of nonlinear multivariable MDS mechanical vibration systems, such as discrete zero dynamics and asymptotic stability, are examined. The resulting time-discretization provides discrete dynamics behavior for nonlinear MDS mechanical vibration systems, which enabling the application of existing controller design techniques. The ideas presented here generalize well-known results from the linear case to nonlinear plants

Ride comfort analysis of a nonlinear vehicle excited by the consecutive speed-control humps

The consecutive speed-control humps (SCHs) possess the function of controlling speed forcibly, but cause violent vibration of a vehicle inevitably. This paper tries to further explore the inherent link among parameters of the SCHs, velocity and vehicle vibration. A 4-DOF nonlinear half-vehicle model with nonlinear springs and nonlinear dampers is established. The consecutive SCHs-speed coupling excitation function is presented by combination of trapezoidal and sine wave of constant amplitude and variable frequency. The nonlinear dynamics of half-vehicle model is investigated by numerical simulation. It reveals that various forms of vibrations, such as periodic, quasi-periodic and chaotic vibrations, could appear in the system with the change of the velocity. Further it is found that quasi-periodic motions will affect vehicle ride comfort most and can be avoided by changing parameters of the consecutive SCHs. Results are conductive to deep understanding of nonlinear vibration in vehicle and rational design of the consecutive SCHs

Transient Climate Response in Coupled Atmospheric–Ocean General Circulation Models

The equilibrium climate sensitivity (ECS) has a large uncertainty range among models participating in the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4) and has recently been presented as “inherently unpredictable.” One way to circumvent this problem is to consider the transient climate response (TCR). However, the TCR among AR4 models also differs by more than a factor of 2. The authors argue that the situation may not necessarily be so pessimistic, because much of the intermodel difference may be due to the fact that the models were run with their oceans at various stages of flux adjustment with their atmosphere. This is shown by comparing multimillennium-long runs of the Goddard Institute for Space Studies model, version E, coupled with the Hybrid Coordinate Ocean Model (GISS-EH) and the Community Climate System Model, version 4 (CCSM4) with what were reported to AR4. The long model runs here reveal the range of variability (~30%) in their TCR within the same model with the same ECS. The commonly adopted remedy of subtracting the “climate drift” is ineffective and adds to the variability. The culprit is the natural variability of the control runs, which exists even at quasi equilibration. Fortunately, for simulations with multidecadal time horizon, robust solutions can be obtained by branching off thousand-year-long control runs that reach “quasi equilibration” using a new protocol, which takes advantage of the fact that forced solutions to radiative forcing forget their initial condition after 30–40 yr and instead depend mostly on the trajectory of the radiative forcing

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice

Discrete dynamics analysis for nonlinear collocated multivariable mass-damper-spring intelligent mechanical vibration systems

A new time-discretization method for the development of nonlinear collocated multivariable mass-damper-spring (MDS) intelligent mechanical vibration systems is proposed. It is based on the Runge-Kutta series expansion method and zero-order hold assumption. In this paper, we show that the mathematical structure of the new discretization scheme is explored and characterized in order to represent the discrete dynamics properties for nonlinear collocated multivariable MDS intelligent mechanical vibration systems. In particular, the decent effects of the time-discretization method on key properties of nonlinear multivariable MDS mechanical vibration systems, such as discrete zero dynamics and asymptotic stability, are examined. The resulting time-discretization provides discrete dynamics behavior for nonlinear MDS mechanical vibration systems, which enabling the application of existing controller design techniques. The ideas presented here generalize well-known results from the linear case to nonlinear plants

4-But­oxy-3-(2,4-dichloro­phen­yl)-1-oxaspiro­[4.5]dec-3-en-2-one

In the title compound, C19H22Cl2O3, the cyclo­hexane ring adopts a chair conformation. The furan ring plane forms dihedral angles of 81.88 (2) and 50.19 (3)°, respectively, with the benzene ring and the plane formed by the butyl C atoms. The crystal structure is stabilized by weak inter­molecular C—H⋯O hydrogen bonds

Comparative Cytogenetics Analysis of Chlamys farreri, Patinopecten yessoensis, and Argopecten irradians with C0t-1 DNA by Fluorescence In Situ Hybridization

The chromosomes of Chlamys farreri, Patinopecten yessoensis, and Argopecten irradians were studied by FISH using C. farreri C0t-1 DNA probes. The results showed that C0t-1 DNA signals spread on all chromosomes in the three scallops, whereas signal density and intensity were different strikingly. Clustering brighter signals presented in the centromeric and telomeric regions of most C. farreri chromosomes, and in the centromeric or pericentromeric regions of several P. yessoensis chromosomes. Comparative analysis of the mapping indicated a relatively higher homology in the repetitive DNA sequences of the genome between C. farreri and P. yessoensis than that between C. farreri and A. irradians. In addition, FISH showed that the distribution of C0t-1 DNA clustering signals in C. farreri displayed completely similar signal bands between homologous chromosomes. Based on the C0t-1 DNA fluorescent bands, a more exact karyotype of C. farreri has been obtained. In this study, the comparative analysis based on C0t-1 DNA provides a new insight into the chromosomal reconstructions during the evolution process, and it is helpful for understanding an important source of genomic diversity, species relationships, and genome evolution

Cationic liposomes induce cytotoxicity in HepG2 via regulation of lipid metabolism based on whole-transcriptome sequencing analysis

Abstract Backgroud Cationic liposomes (CLs) can be used as non-viral vectors in gene transfer and drug delivery. However, the underlying molecular mechanism of its cytotoxicity has not been well elucidated yet. Methods We herein report a systems biology approach based on whole-transcriptome sequencing coupled with computational method to identify the predominant genes and pathways involved in the cytotoxicity of CLs in HepG2 cell line. Results Firstly, we validated the concentration-dependent cytotoxicity of CLs with an IC50 of 120 μg/ml in HepG2 exposed for 24 h. Subsequently, we used whole-transcriptome sequencing to identify 220 (77 up- and 143 down-regulated) differentially expressed genes (DEGs). Gene ontology (GO) and pathway analysis showed that these DEGs were mainly related to cholesterol, steroid, lipid biosynthetic and metabolic processes. Additionally, “key regulatory” genes were identified using gene act, pathway act and co-expression network analysis, and expression levels of 11 interested altered genes were confirmed by quantitative real time PCR. Interestingly, no cell cycle arrest was observed through flow cytometry. Conclusions These data are expected to provide deep insights into the molecular mechanism of CLs cytotoxicity.https://deepblue.lib.umich.edu/bitstream/2027.42/144776/1/40360_2018_Article_230.pd

A controllable superconducting electromechanical oscillator with a suspended membrane

We fabricate a microscale electromechanical system, in which a suspended superconducting membrane, treated as a mechanical oscillator, capacitively couples to a superconducting microwave resonator. As the microwave driving power increases, nonmonotonic dependence of the resonance frequency of the mechanical oscillator on the driving power has been observed. We also demonstrate the optical switching of the resonance frequency of the mechanical oscillator. Theoretical models for qualitative understanding of our experimental observations are presented. Our experiment may pave the way for the application of a mechanical oscillator with its resonance frequency controlled by the electromagnetic and/or optical fields, such as a microwave-optical interface and a controllable element in a superqubit-mechanical oscillator hybrid system.Comment: 8 pages,4 figure